In the rare instance where a malignant phyllode tumor spreads, it tends to behave more like a soft tissue form of cancer (sarcoma) than other forms of breast cancer. They tend to respond differently than other forms of breast cancer, and are usually treated with removal of the tumor and a small portion of surrounding healthy breast tissue, or with mastectomy. Truly malignant phyllodes tumors are generally rare, accounting for roughly 5% of all cases. Phyllodes tumors can sometimes regrow once they have been removed. For this reason, the entire tumor is typically removed for proper evaluation. ![]() The main distinction between a phyllodes tumor and a fibroadenoma is an overgrowth of connective tissue in a phyllodes tumor, which can appear as abnormal cells in diagnostic imaging tests.
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